Sequential hollowfiber liquid phase microextraction for the. Hollow fiberbased liquid phase microextraction followed by. The applicability of hollow fiberbased liquid phase microextraction hflpme was evaluated for the extraction and preconcentration of three antidepressant drugs amitriptyline, imipramine and sertraline prior to their determination by hplcuv. The effect of extraction parameters including ph of the feed solution, stirring rate. In the socalled functionalized tio2 hollow fiber solid liquid phase microextraction method, the acceptor phase is functionalized tio2 nanoparticles that are dispersed in the organic solvent and held in the pores and lumen of a porous polypropylene hollow fiber membrane. A new analytical method for the simultaneous determination of the antidiabetic drugs rosiglitazone ros and metformin hydrochloride mh with marked. Developments in hollow fiber based liquidphase microextraction. In highthroughput ultrasonication enhanced hollow fiber liquid phase microextraction huhflpme, ultrasonication was introduced into hflpme to enhance the mass transfer rate of the analytes in the two immiscible liquid phases, which resulted in a very short time for extraction equilibrium and a highthroughput analysis. Trace determination of tamoxifen in biological fluids using. Lpme method was established for purification and enrichment of glutathione gsh in human saliva followed by a miniaturized capillary electrophoresis with amperometric detection system mini. For the first time, hollowfiber liquidphase microextraction combined with highperformance liquid chromatographyultraviolet was used to extract trans, transmuconic acid, in urine samples of workers who had been exposed to benzene.
Article views are the countercompliant sum of full text article downloads since november 2008 both pdf and html across all institutions and individuals. Highthroughput determination of nicotine in plasma by. A novel application of three phase hollow fiber based. Toluene functioned as both the extraction solvent and the impregnation solvent. Hollowfiber liquidphase microextraction hflpme is commonly used to minimize consumption of organic solvent for extraction and to protect the extraction phase from contamination or depletion 110. Ultrasoundmixing was used as an assisted method to accelerate the mass transfer and minimize fluid. Ligand assisted pseudostir bar hollow fiber solidliquid phase microextraction using solgel sorbent reinforced with carbon nanotubes was combined with differential pulse anodic stripping voltammetry for simultaneous determination of cadmium and lead in tap. Extraction and determination of three chlorophenols by hollow. Solid phase microextraction with thermal desorption using. Yanmin zou, zhen zhang, xiaoling shao, yao chen, xiangyang wu, liuqing yang, jingjing zhu, dongmei zhang. For the first time, hollow fiber liquid phase microextraction combined with highperformance liquid chromatographyultraviolet was used to extract trans, transmuconic acid, in urine samples of workers who had been exposed to benzene. Hollow fiberliquid phase microextraction is more cumbersome compared to sdme because of the need to prepare disposable hollow fibers, and.
A new sampling method, termed negligible depletion hollow fiberprotected liquid. A simple and solvent minimized sample preparation technique based on twophase hollow fiberprotected liquidphase microextraction was investigated for hplc analysis of selected pesticides in water samples. Hollow fiberbased liquid phase microextraction combined. Hollow fibre liquidphase microextraction principles, performance. An sfme composed of toluene, isopropanol, and water was used to reinforce hf. In this study, a simple and efficient hollow fiber liquid phase microextraction hflpme method coupled with high performance liquid chromatography has been developed for preconcentration and determination of cabergoline in plasma and urine samples. Dec 05, 2007 the applicability of hollow fiber based liquid phase microextraction hflpme was evaluated for the extraction and preconcentration of three antidepressant drugs amitriptyline, imipramine and sertraline prior to their determination by hplcuv. The carbonsorbentreinforced hollow fiber liquid phase microextraction afforded higher extraction efficiency and shorter extraction time compared with conventional hollow fiber liquid phase microextraction. This chapter discusses hollow fiber liquid phase microextraction lpme. For the analysis of polar or ionizable analytes, a threephase system is frequently used with an organic solvent immobilized in the hollowfiber. In recent years, liquid phase micro extraction lpme methods minimizing organic solvent used in liquidliquid extraction are developed. Determination of conjugated estrogens in human urine using carriermediated hollow fiber liquid phase microextraction and lcmsms. Hollowfibersupported liquidphase microextraction using an ionic liquid as the extractant for the preconcentration of bisphenol a, 17.
Sdme in its original form, first described by jeannot and cantwell in 1996 24, is. Hollow fiber liquid phase microextraction followed by high performance liquid chromatography for determination of ultratrace levels of seiv after derivatization in urine, plasma and natural water samples. Dec 22, 2016 a novel application of three phase hollow fiber based liquid phase microextraction hflpme for the hplc determination of two endocrine disrupting compounds edcs, noctylphenol and n. In highthroughput ultrasonication enhanced hollowfiber liquidphase microextraction huhflpme, ultrasonication was introduced into hflpme to enhance the mass transfer rate of the analytes in the two immiscible liquid phases, which resulted in a very short time for extraction equilibrium and a highthroughput analysis. A new microextraction technique termed hollow fiber protected liquid phase microextraction lpme was developed. Determination of conjugated estrogens in human urine using. Application of hollow fiber liquid phase microextraction and. Hollow fiberprotected liquidphase microextraction of. Applications of these newly emerging developments in extraction. Determination of metal ions by ultrasound assisted hollow. Determination of organochlorine pesticides in water. The drug was extracted from a 15 ml aqueous sample source phase. Liquidphase microextraction an overview sciencedirect. Development of hollowfiber liquidphase microextraction method.
Both methods allow the direct transfer of extracted analytes to a gcms system for analysis. Ligand assisted pseudostir bar hollow fiber solidliquid phase microextraction using solgel sorbent reinforced with carbon nanotubes was combined with differential pulse anodic stripping voltammetry for simultaneous determination of cadmium and lead in tap water, and darongar river water samples. Hollowfiber liquidphase microextraction and chiral lcms. The twophase system was developed one year later rasmussen et al. The three main approaches to lpme are single drop microextraction sdme, hollow fiber liquidphase microextraction hflpme and dispersive liquidliquid microextraction dllme. Tamsulosin is used for the treatment of difficult urination, a common symptom of an enlarged prostate. A new hollow fiber liquidsolid phase microextraction using. A new hollow fiber liquidsolid phase microextraction for extraction of ginsenosides from a chinese compound formula was established using al2o3 nanoparticles as the adsorbent. Four pesticides procymidon, methidation, quinalphos, and vinclozolin were considered as target analytes. Sdme in its original form, first described by jeannot and cantwell in 1996 24, is the simplest way to perform lpme. Liquidphase microextraction an overview sciencedirect topics.
The limits of detection sn 3 and quantification sn 10 of bps in human urine samples are 0. Pdf developments in hollow fiber based liquidphase. The enhancement technique involved dispersing al 2 o 3 particles in nbutanol to fill the pores and lumen of a polyether sulfone membrane fiber. Hollow fiber based liquid phase microextraction combined. The method includes a cleanup and preconcentration stage 750. Applications of liquidphase microextraction in the sample. For the first time, hollowfiber liquidphase microextraction combined with highperformance liquid chromatographyultraviolet was used to extract trans,transmuconic acid, in urine samples of workers who had been exposed to benzene. A simple and highly sensitive method that involves miniaturized hollow fiber assisted liquidphase microextraction hflpme with in situ acyl derivatization and gcms was developed for the determination of benzophenone bp and related compounds in human urine samples. Hollow fiber liquidphase microextraction hflpme offers an efficient alternative to classical techniques for sample preparation and preconcentration. Ligand assisted pseudostir bar hollow fiber solidliquid phase microextraction using solgel sorbent reinforced with carbon nanotubes was combined with differential pulse anodic stripping voltammetry for simultaneous determination of cadmium. Pdf application of hollowfiberassisted liquidphase. Hollow fiber liquid phase microextraction hflpme offers an efficient alternative to classical techniques for sample preparation and preconcentration. This chapter discusses hollow fiber liquidphase microextraction lpme.
Hollowfiber liquidphase microextraction and chiral lcmsms. Comparison between solid phase microextraction spme and. Determination of polycyclic aromatic hydrocarbons in fresh. Development of miniaturized hollowfiber assisted liquid. Pdf hollow fiber liquid phase microextraction followed. A simple and highly sensitive method that involves three phase hollow fiber supported liquid phase microextraction hflpme coupled with maltodextrin mdmodified capillary electrophoresis ce was successfully developed for the separation and determination of trace concentrations of citalopram cit enant. A novel extraction technique for the measurement of caffeic acid in echinacea purpurea herbal extracts combined with highperformance liquid chromatography, j. Scanning electron microscope characterizations indicated that graphene oxide was successfully synthesized and modified in the pores of hf by ultrasonication. Hollowfibersupported liquidphase microextraction using. Application of hollow fiber assisted liquid phase microextraction to identify avermectins in stream water using msms.
Sdme in its original form, first described by jeannot and cantwell in 1996 24. An effective and sensitive method to determinate four parabens was developed by using graphene oxide goreinforced hollow fiber hf solidphase microextraction combined with hplcpda. Hollow fiber based liquid phase microextraction combined high. Cabergoline was extracted from 15 ml of basic sample solution with ph of 10 into an organic extracting. The applicability of hollow fiber liquidphase microextraction hflpme combined with highperformance liquid chromatographyultraviolet detection hplcuv was evaluated for the extraction and determination of tamoxifen tam in biological fluids including human urine and plasma. Liquidliquid lle extraction is commonly used in preparation of the samples. Extraction of cuii ions in wastewaters using new solid. Liquidphase microextraction combined with hollow fiber as a. Hollow fiber liquid phase microextraction followed by high performance liquid chromatography for determination of ultratrace levels of seiv after derivatization in. The enhancement technique involved dispersing al2o3 particles in nbutanol to fill the pores and lumen of a polyether sulfone membra. An sfme composed of toluene, isopropanol, and water was. Apr 11, 2015 for the first time, the surfactantfree microemulsion reinforced hollow fiber liquid phase microextraction sfmehflpme was developed for the determination of phthalic acid esters paes followed by fieldenhanced sample injection with reverse migrating micelles fesirmm in capillary electrophoresis.
Application of hollow fiber liquid phase microextraction. Surfactantfree microemulsion reinforced hollowfiber liquid. A novel method for determination of organochlorine pesticides residuals 2,4ddt and 4,4ddt in water samples through hollow fiber membraneliquid phase microextraction using ionic liquid material as extractant coupled with high performance liquid chromatography has been developed. A new hollow fiber liquidsolid phase microextraction for extraction of ginsenosides from a chinese compound formula was established using al 2 o 3 nanoparticles as the adsorbent. The applicability of hollow fiber liquid phase microextraction hflpme combined with highperformance liquid chromatographyultraviolet detection hplcuv was evaluated for the extraction and determination of tamoxifen tam in biological fluids including human urine and plasma. Twophase hollow fiber liquidphase microextraction request pdf.
The organic membrane solventconsists of 1octanol immobilized in the pores of a hollow fiber. The sampling device was prepared by impregnating 1. The two phase system was developed one year later rasmussen et al. Pdf hollow fiber liquidphase microextraction hflpme offers an efficient alternative to classical techniques for sample preparation and. Development of negligible depletion hollow fiberprotected. Finally, the method was applied to the analysis of real water samples, such as drinking water, tap water, and swimming pool water samples. Enantiomers of guaifenesin an expectorant drug were investigated as a model system. Hollow fiberbased liquid phase microextraction hflpme. Hollowfiber liquidphase microextraction hflpme and electromembrane extraction eme are miniaturized extraction techniques, and have been coupled. A new microextraction technique termed hollow fiberprotected liquidphase microextraction lpme was developed. Features include high selectivity, good enrichment factors, and improved possibilities for automation. Sequential hollow fiber liquid phase microextraction for the determination of rosiglitazone and metformin hydrochloride antidiabetic drugs in biological fluids.
A new hollow fiber liquidsolid phase microextraction. Of these methods, hollow fiber liquid phase micro extraction hflpme is widely used. In this microextraction technique, a waterimmiscible organic solvent was immobilized in the pores of a porous hollow fiber, and formed a supported liquid membrane. Different factors that can affect the extraction process such as extraction solvent, acceptor and donor phase composition, salt addition, stirring rate, extraction. A new method for the determination of four endocrine disrupting compounds edcs bisphenol a, 17. Application of hollowfiberassisted liquidphase microextraction to identify avermectins in stream water using msms. After hf lpme optimization the following condition was established. A simple and highly sensitive method that involves threephase hollow fiber supported liquidphase microextraction hflpme coupled with maltodextrin mdmodified capillary electrophoresis ce was successfully developed for the separation and determination of trace concentrations of citalopram cit enantiomers in urine samples. The lumen of the hollow fiber was filled with microliter amounts of an acceptor phase. Sequential hollowfiber liquid phase microextraction for. Hollow fiber liquidphase microextraction request pdf. In this work, a novel approach, ultrasoundassisted hollow fibre liquidphase microextraction uahflpme was used for the preconcentration of cd, cu, and cr from environmental samples by faas.
In this paper, a three phase hollow fiber based liquid phase microextraction hflpme combined with a hplc procedure using diode array dad and fluorescence detection fld has been developed for the determination of eight widely used fluoroquinolones. Qi decoction and the single herb, fructus aurantii immaturus, cortex magnoliae. Hplpme relies on the extraction of target analytes from aqueous samples into a supported liquid membrane slm sustained in the pores of. For the analysis of polar or ionizable analytes, a three phase system is frequently used with an organic solvent immobilized in the hollow fiber. The chapter comprises a short discussion of the basic setup and principles for lpme, and the historical development. Recently, hollow fiber liquid phase micro extraction hflpme, based on the application of a supported liquid membrane, was. For this reason a twophase hollow fiber liquid phase microextraction method for the. A hollow fiber liquid phase microextraction hflpme combined with ultrahigh performance liquid chromatographytandem mass spectrometry uhplcmsms method was developed for the extraction and. Sequential hollowfiber liquid phase microextraction for the determination of rosiglitazone and metformin hydrochloride antidiabetic drugs in biological fluids. Hplpme relies on the extraction of target analytes from aqueous samples into a supported liquid membrane. For the first time, the surfactantfree microemulsion reinforced hollowfiber liquidphase microextraction sfmehflpme was developed for the determination of phthalic acid esters paes followed by fieldenhanced sample injection with reverse migrating micelles fesirmm in capillary electrophoresis. Hollowfibersupported liquidphase microextraction using an.
In this work, a twophase hollow fiber liquidphase microextraction hflpme method combined with gas chromatographymass spectrometry gcms is developed to provide a rapid, selective and sensitive analytical method to determine polycyclic aromatic hydrocarbons pahs in fresh milk. Trace determination of tamoxifen in biological fluids. A novel application of three phase hollow fiber based liquid. Recently, hollowfiber liquidphase micro extraction hflpme, based on the application of a supported liquid membrane, was introduced using a porous. Liquid phase microextraction or solvent microextraction was developed as a fast, simple and inexpensive solventminimized liquid liquid extraction lle technique 8 9. Hollow fiber liquid phase microextraction hflpme is commonly used to minimize consumption of organic solvent for extraction and to protect the extraction phase from contamination or depletion 110. The method employed lcmsms analysis and hollowfiber liquidphase microextraction hf lpme for sample preparation. Development of hollowfiber liquidphase microextraction. Hollow fiber liquid phase microextraction hflpme and solid phase microextraction spme methods for preconcentration of contaminants toluene, benzophenone, tetracosane and chloroform in food simulants were investigated. A new procedure is presented for the determination of low concentrations of lead and cadmium in water samples. Abstractthe extraction conditions of the conjugated estrogens, including estrone3glucuronide eg, 17. They presented the three phase system where the pores of the fiber were impregnated with an organic solvent and the lumen contained an acceptor aqueous solution. Hollow fiber liquidphase microextraction hflpme technique has been shown to be a reliable and valid in measuring trace amount of different.
The parameters affecting the metabolite extraction were optimized as follows. Hollow fiberbased liquid phase microextraction combined with. Extraction and determination of three chlorophenols by. Applications of these newly emerging developments in extraction and preconcentration of a vast category of compounds including heavy metals, pesticides, pharmaceuticals and abused drugs in complex matrices environmental and biological. They presented the threephase system where the pores of the fiber were impregnated with an organic solvent and the lumen contained an acceptor aqueous solution. Hollow uber based liquid phase microextraction hflpme followed by high performance liquid chromatography hplc coupled with ultraviolet uv detection was used for extraction of methylphenidate hydrochloride. Some important extraction parameters, such as effect of salt. For hflpme 1heptanol, 2octanone and dibutylether were studied as extracting solvents. Hollowfiber liquidphase microextraction followed by high. Carbon nanotube assisted solgel based hollow fiber. We report the application of the dispersive liquidliquid microextraction coupled to hollowfibre membraneassisted liquidphase microextraction and its application for extraction of atrazine and triclosan.
Surfactantfree microemulsion reinforced hollowfiber. A novel application of three phase hollow fiber based liquid phase microextraction hflpme for the hplc determination of two endocrine disrupting compounds edcs, noctylphenol and n. Application of hollow fiber liquid phase microextraction for. Pdf hollow fiber liquid phase microextraction followed by. Hollow fiber supported liquidphase microextraction. Liquidphase microextraction or solvent microextraction was developed as a fast, simple and inexpensive solventminimized liquidliquid extraction lle technique 8 9. Hollow fiber supported liquidphase microextraction combined. Triazines were employed as model compounds to assess the extraction procedure and were determined by gas chromatographymass spectrometry. In the socalled functionalized tio2 hollow fiber solidliquidphase microextraction method, the acceptor phase is functionalized tio2 nanoparticles that are dispersed in the organic solvent and held in the pores and lumen of a porous polypropylene hollow fiber membrane. Hollow fiber liquidphase microextraction hflpme offers an efficient alternative to classical techniques for sample preparation and.
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